This OTJR: Occupation, Participation, and Health journal article describes a study on relationships between these factors and depression in middle-aged adults with physical disabilities during the early stages of the COVID-19 pandemic. The authors also provided recommendations for OTs looking to address symptoms of depression in their clients. Participants in a larger study of people aging with long-term physical disabilities (ages 45–64) completed a supplemental survey with questions about COVID-19, depression, and factors associated with depression. The authors analyzed the data and found that financial stress, loneliness, and anxiety all predicted depressive symptoms. Anxiety was the strongest predictor. We also found associations for race and previous depression diagnosis: Black participants and participants with no history of depression had lower levels of depressive symptoms. A summary of the article is available from the project (PDF).