Study examined the impact of the coronavirus disease 2019 (COVID-19) pandemic on the lives of people with mental health disorders. The results showed that more than one-third (35.1 percent) screened positive for generalized anxiety disorder and over one-quarter (29.6 percent) screened positive for major depressive disorder. The majority reported pandemic-related changes in eating and sleeping patterns and exposure to COVID-19 infection. Multivariable logistic regression analysis found that many changes attributed to the pandemic were positively and significantly associated with screening positive for anxiety and depressive disorders. Qualitative analysis confirmed these findings and identified participants’ resilience stemming from social support, emotion management, and self-care. Published in the journal Translational Behavioral Medicine