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Physical and cognitive functioning after 3 years can be predicted using information from the diagnostic process in recently diagnosed multiple sclerosis.
Archives of Physical Medicine and Rehabilitation
, Volume 90(9)
, Pgs. 1478-1488.
NARIC Accession Number: J57185.
ISSN: 0003-9993.
Author(s): de Groot, Vincent; Beckerman, Heleen; Uitdehaag, Bernard M.; Hintzen, Rogier Q.; Minneboo, Arjan; Heymans, Martijn W.; Lankhorst, Gustaaf J.; Polman, Chris H.; Bouter, Lex M..
Publication Year: 2009.
Number of Pages: 11.
Abstract: Study examined the utility of prediction models to predict functioning after 3 years in patients with recently diagnosed multiple sclerosis (MS). One hundred fifty-six patients with MS were recruited for the study; 146 had complete data on outcomes at the 3-year follow-up. At baseline, the following predictors were selected from medical history taking, neurologic examination, and magnetic resonance imaging (MRI): inability to walk at least 500 meters, impaired dexterity, cognitive impairments, incontinence, inability to drive a car or use public transportation, social dysfunction, and reliance on a disability pension. Clinical prediction rules were constructed for the models that were well calibrated and that showed sufficient discrimination after internal bootstrap validation. The models for the inability to walk at least 500 meters, impaired dexterity, and cognitive impairments were well calibrated. Discrimination was sufficient for all 7 models, except the one predicting social dysfunction (.67). The inability to walk at least 500 meters was predicted by the perceived ability to walk, impairment of the cerebellar tract, and the number of MRI lesions in the spinal cord. Impaired dexterity was predicted by the perceived ability to use the hands, impairments of the pyramidal, cerebellar, and sensory tracts, and the T2-weighted infratentorial lesion load. Cognitive impairment was predicted by age, gender, the perceived ability to concentrate, and the T2-weighted supratentorial lesion load.
Descriptor Terms: AMBULATION, COGNITION, DEXTERITY, DISABILITY INSURANCE, FOLLOW UP, FUNCTIONAL STATUS, INCONTINENCE, MODELING, MULTIPLE SCLEROSIS, OUTCOMES, PREDICTION, SOCIAL SKILLS, TRAVEL, .
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Archives of Physical Medicine and Rehabilitation.
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